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Target intelligence / Profile preview
C-X-C Chemokine Receptor Type 2 (CXCR2)
- Target
- CXCR2
- Molecular classification
- G protein-coupled receptor
01
Overview
C-X-C chemokine receptor type 2 (CXCR2) is a G protein-coupled receptor that binds CXC chemokines. It is expressed on neutrophils and mediates immune cell migration, inflammation, and tumor growth. Inhibitors targeting this receptor are being explored as therapeutics.
- Other names
- C-X-C motif chemokine receptor 2
02
Mechanism of action
Targeted inhibition under investigation for oncology/inflammatory uses
03
Biological functions
Neutrophil activationNeutrophil migrationCalcium signalingLeukocyte traffickingImmune responseCell surface receptor signaling
04
Disease associations
Cancer progressionMetastasisInflammation
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