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Target intelligence / Profile preview
C-X-C Chemokine Receptor Type 3A (CXCR3A)
- Target
- CXCR3A
- Molecular classification
- G protein-coupled receptor, Chemokine receptor, Receptor
01
Overview
C-X-C chemokine receptor type 3A (CXCR3A) is a G protein-coupled receptor primarily involved in immune cell trafficking. It binds to CXCL9, CXCL10, and CXCL11, mediating the migration of activated T cells and other leukocytes to sites of inflammation or tissue injury. It plays a role in type 1 immune responses, autoimmune pathology, and cancer.
- Other names
- CXCR3G protein-coupled receptor 11GPR11CD183 antigen
02
Mechanism of action
Pharmacological inhibition or modulation
03
Biological functions
Signal transductionChemotaxisImmune responseCell migrationCell proliferationModulation of cell survival
04
Disease associations
Autoimmune diseasesCancerInflammatory diseasesMultiple sclerosisPrimary biliary cholangitis
05
Safety considerations
Potential for immunosuppressionOff-target effects due to broad expression
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