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Target intelligence / Profile preview
C-X-C Chemokine Receptor Type 5 (CXCR5)
- Target
- CXCR5
- Molecular classification
- G protein-coupled receptor (GPCR), CXC chemokine receptor family, Receptor
01
Overview
CXCR5 is a seven-transmembrane GPCR that specifically binds the chemokine ligand CXCL13. The primary function of this interaction is to mediate the migration of immune cells, particularly B cells and certain T cell subsets, into lymphoid follicles within secondary lymphoid organs such as lymph nodes, spleen, and Peyer’s patches. It is essential for guiding B cell migration into follicles for proper immune responses and critical for positioning both B and Tfh/Tfr cells during germinal center reactions—key to high-affinity antibody production through class switching. Its dysregulation is implicated in autoimmune diseases and cancers.
- Other names
- CD185Burkitt lymphoma receptor 1 (BLR1)BLR1MDR15
02
Mechanism of action
CXCR5 binds to CXCL13, mediating the migration of immune cells, particularly B cells and certain T cell subsets, into lymphoid follicles within secondary lymphoid organs.
03
Biological functions
Lymphocyte migrationHoming to folliclesOrganization/development of secondary lymphoid organsImmune responseSignal transduction
04
Disease associations
Autoimmune diseases (Rheumatoid arthritis, Multiple Sclerosis, Systemic Lupus Erythematosus, Sjögren’s syndrome, Myasthenia Gravis, Inflammatory Bowel Disease)Cancers (Lymphoma, Leukemia, Pancreatic carcinoma)InflammationInfectious diseases
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