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Target intelligence / Profile preview
C-X-C motif chemokine 10 (CXCL10)
- Target
- CXCL10
- Molecular classification
- Chemokine, Cytokine
01
Overview
C-X-C motif chemokine 10 (CXCL10), also known as Interferon gamma-induced protein 10 (IP-10), is a small pro-inflammatory cytokine belonging to the CXC chemokine family. It is secreted by various cell types in response to interferon-gamma (IFN‑γ) and exerts its biological effects primarily through binding to the chemokine receptor CXCR3 on target immune cells, leading to immune cell migration.
- Other names
- IP-10Small-inducible cytokine B10SCYB10GIP-10IFI10INP10Crg-2Mob-1
02
Mechanism of action
CXCL10 exerts its biological effects primarily through binding to the chemokine receptor CXCR3 on target immune cells. This axis mediates signal transduction leading to immune cell migration.
03
Biological functions
ChemotaxisImmune cell migrationAngiogenesis inhibitionRegulation of cell growthT-cell adhesion
04
Disease associations
Autoimmune disordersCardiovascular diseaseKidney diseasesViral infectionsInflammation
05
Biomarkers
Disease severity in kidney diseasesInflammatory/autoimmune conditionsViral infections
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