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Target intelligence / Profile preview
C-X-C Motif Chemokine Ligand 10 (CXCL10)
- Target
- CXCL10
- Molecular classification
- CXC chemokine, Chemokine, Cytokine
01
Overview
CXCL10, also known as IP-10, is a chemokine secreted by various cell types in response to IFN-γ. It acts primarily through the CXCR3 receptor to attract and activate immune cells, playing a critical role in inflammation, immune responses, and tissue damage. It is also involved in anti-tumor activity and inhibition of angiogenesis. Aberrant CXCL10 expression is associated with numerous diseases, making it a potential biomarker and therapeutic target.
- Other names
- IP-10Interferon gamma-induced protein 10Small-inducible cytokine B10
02
Mechanism of action
CXCL10 binds to the CXCR3 receptor, leading to downstream signaling events that promote leukocyte migration, adhesion, and activation. Its anti-angiogenic activity is mediated through inhibition of endothelial cell proliferation and migration.
03
Biological functions
ChemoattractionImmune cell recruitmentT cell adhesionImmune activationAntiangiogenic activityInhibition of bone marrow colony formation
04
Disease associations
Spotted feverCryptosporidiosisRenal diseasesLupus nephritisRenal allograft dysfunctionAutoimmune disordersJuvenile dermatomyositisInfectionInflammation
05
Safety considerations
Dysregulation can contribute to chronic inflammation and autoimmune diseasesElevated levels post-vaccination may indicate excessive inflammation
06
Biomarkers
Serum CXCL10 levels (disease severity/prognosis)CSF CXCL10 levels (disease severity/prognosis)
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