C-X-C motif chemokine ligand 10 mRNA (CXCL10 mRNA)

CXCL10 mRNA is the messenger RNA transcript that encodes the C-X-C motif chemokine ligand 10 (CXCL10), a potent pro-inflammatory cytokine also known as IP-10 [1]. This mRNA is primarily transcribed in response to interferon-gamma (IFN-γ) stimulation in various cell types, including monocytes, endothelial cells, and fibroblasts [2]. Once translated, the resulting CXCL10 protein acts as a ligand for the CXCR3 receptor, driving the recruitment of Th1 lymphocytes and NK cells to sites of inflammation [3]. Overexpression of CXCL10 mRNA is a hallmark of several Th1-driven autoimmune and inflammatory conditions, such as rheumatoid arthritis, inflammatory bowel disease, and type 1 diabetes [4]. In the context of infectious diseases, elevated CXCL10 mRNA levels are associated with the cytokine storm observed in severe viral infections like COVID-19 [5]. While clinical therapeutics like eldelumab target the secreted protein, CXCL10 mRNA is an active target for experimental RNA interference (RNAi) and antisense oligonucleotide (ASO) therapies aimed at reducing chemokine production at the source [6]. Furthermore, the detection of CXCL10 mRNA in clinical samples, particularly urine, serves as a non-invasive biomarker for diagnosing acute cellular rejection in kidney transplant recipients [7].

Other names

IP-10 mRNAInterferon gamma-induced protein 10 mRNASmall inducible cytokine subfamily B member 10 mRNASCYB10 mRNAC-X-C motif chemokine 10 mRNA

RNA interference or antisense-mediated degradation of the mRNA transcript to prevent translation of the CXCL10 protein.