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Target intelligence / Profile preview
C-X-C motif chemokine ligand 2 (CXCL2)
- Target
- CXCL2
- Molecular classification
- Chemokine, CXC chemokine family, Cytokine, Endogenous peptide
01
Overview
CXCL2 (C-X-C motif chemokine ligand 2) is a small cytokine belonging to the CXC chemokine family. It acts mainly as a chemoattractant for polymorphonuclear leukocytes—especially neutrophils—and hematopoietic stem cells. Its primary receptor on target cells is CXCR2. Elevated expression of CXCL2 has been observed in various pathological states, including obesity and stomach adenocarcinoma, and is implicated in immunoregulatory/inflammatory diseases.
- Other names
- MIP-2αGROβGro-oncogene-2SCYB2GRObMGSA-b
02
Biological functions
Neutrophil chemoattractionImmune response modulationWound healingAngiogenesisHematopoiesis regulationLeukocyte traffickingLeukocyte activation
03
Disease associations
ObesityStomach adenocarcinomaImmunoregulatory diseasesInflammatory diseasesAsthmaCancer metastasis
04
Biomarkers
Prognostic biomarker in stomach adenocarcinoma
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