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Target intelligence / Profile preview
C-X-C Motif Chemokine Ligand 3 (CXCL3)
- Target
- CXCL3
- Molecular classification
- Chemokine, Cytokine, CXC chemokine
01
Overview
CXCL3, also known as chemokine (C-X-C motif) ligand 3, is a small cytokine belonging to the CXC chemokine family. It acts primarily through the CXCR2 receptor, mediating neutrophil chemotaxis and inflammation. It plays roles in tumorigenesis through tumor cell differentiation, invasion and migration. High levels correlate with advanced tumor stage, high grade tumors, lymph node metastasis, poor prognosis. It is also referred to as GROγ (GRO protein gamma), GRO3 oncogene, and macrophage inflammatory protein-2-beta (MIP2b).
- Other names
- GROγGRO protein gammaMIP2bGRO oncogene
02
Mechanism of action
CXCR2 receptor agonist
03
Biological functions
ChemotaxisInflammationCell migrationCell proliferationTumor cell differentiationInvasion
04
Disease associations
CancerInflammation
05
Safety considerations
Potential for off-target effects due to interaction with other CXC receptorsPromotes tumor cell differentiation, invasion and migrationHigh expression correlates with poor prognosis in some cancers
06
Biomarkers
Elevated CXCL3 expression
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