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Target intelligence / Profile preview
C-X-C motif chemokine ligand 5 (CXCL5)
- Target
- CXCL5
- Molecular classification
- Chemokine, CXC chemokine family, Cytokine
01
Overview
CXCL5 is a small cytokine belonging to the CXC chemokine family, primarily acting as a chemoattractant for neutrophils via interaction with CXCR2. It plays roles in inflammation, angiogenesis, and connective tissue remodeling, and has been implicated in various pathological processes including inflammatory diseases, cancer, cardiovascular disease, and metabolic disorders.
- Other names
- ENA-78SCYB5Epithelial-derived neutrophil-activating peptide 78
02
Mechanism of action
CXCL5 binds primarily to CXCR2 on target leukocytes/neutrophils, modulating their activity. It can also bind Glycosaminoglycans to modulate availability/activity. When bound to GAGs, it cannot activate receptor.
03
Biological functions
Neutrophil chemoattractionNeutrophil migrationAngiogenesisConnective tissue remodelingImmune responseRegulation of B cell recruitment
04
Disease associations
Inflammatory diseasesGouty arthritisSystemic lupus erythematosusCancerAtherosclerosisMetabolic disordersObesity
05
Safety considerations
Promotes tumor formation by recruiting immune cells into tumors.Elevated expression observed in chronic inflammatory conditions like atherosclerosis.
06
Biomarkers
Serum levels in systemic lupus erythematosus patients correlate with platelet counts.
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