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Target intelligence / Profile preview
C-X-C motif chemokine ligand 6 (CXCL6)
- Target
- CXCL6
- Molecular classification
- Chemokine, Cytokine
01
Overview
CXCL6, also known as granulocyte chemotactic protein 2 (GCP-2), is a small cytokine belonging to the CXC chemokine family. It functions primarily as a chemoattractant for neutrophilic granulocytes and plays roles in immune cell recruitment and inflammation. It also has direct antibacterial activity and roles in tissue repair/regeneration.
- Other names
- Granulocyte chemotactic protein 2GCP-2SCYB6CKA-3
02
Mechanism of action
CXCL6 exerts its effects by binding to CXCR1 and CXCR2 receptors, inducing chemotaxis and signaling.
03
Biological functions
ChemotaxisImmune cell recruitmentInflammationAntibacterial activityRegulation of cell permeabilityRegulation of cell proliferationRegulation of apoptosis
04
Disease associations
InflammationFibrosis
05
Safety considerations
Dysregulation or overexpression may contribute to pathological conditions such as chronic inflammation or fibrosis.
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