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Target intelligence / Profile preview
C-X-C Motif Chemokine Ligand 7 (CXCL7)
- Target
- CXCL7
- Molecular classification
- Chemokine, Cytokine, CXC chemokine family, Ligand
01
Overview
CXCL7, also known as C-X-C motif chemokine ligand 7, is a small cytokine belonging to the CXC chemokine family. It is primarily released from platelets upon activation and plays a key role in neutrophil recruitment during tissue injury and inflammation. It signals primarily through CXCR2 and CXCR1 receptors and is implicated in inflammatory diseases and cancer.
- Other names
- Beta-ThromboglobulinPro-Platelet Basic ProteinPPBP
02
Mechanism of action
Targeting the interaction between CXCL7 and its receptors CXCR1 and CXCR2
03
Biological functions
Neutrophil recruitmentMitogenesisCell proliferationExtracellular matrix synthesisWound healingAngiogenesisChemotaxis
04
Disease associations
InflammationCancerTumorigenesisCardiovascular disease
05
Safety considerations
Chronic overexpression may contribute to tumorigenesis through persistent inflammation-driven signaling cascadesPotential for off-target effects when modulating chemokine activity
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