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Target intelligence / Profile preview
C-X-C Motif Chemokine Ligand 9 (CXCL9)
- Target
- CXCL9
- Molecular classification
- Cytokine, Chemokine, CXC chemokine family, Secreted protein
01
Overview
CXCL9 is a chemokine that acts as a chemoattractant primarily for activated T lymphocytes. It is strongly induced by interferon-gamma and plays a significant role in immunoregulatory and inflammatory processes, including anti-tumor immunity. It binds to the CXCR3 receptor to mediate its effects.
- Other names
- Monokine Induced by Gamma InterferonMIGSCYB9Small-Inducible Cytokine B9Crg-10CMKHuMIG
02
Mechanism of action
CXCL9 binds to CXCR3, a G protein-coupled receptor, to induce chemotaxis and activate immune cells.
03
Biological functions
ChemotaxisImmunoregulationInflammationAntimicrobial defenseT cell recruitmentLeukocyte migrationLeukocyte proliferationTissue extravasation
04
Disease associations
Proliferative glomerulonephritisParacoccidioidomycosisImmune-mediated nephritisTumor progressionMetastasisCancer
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