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Target intelligence / Profile preview
C-X-C Motif Chemokine Receptor 1 (CXCR1)
- Target
- CXCR1
- Molecular classification
- G-protein-coupled receptor, Receptor
01
Overview
CXCR1 is a G-protein-coupled receptor that binds the chemokine IL-8/CXCL8 with high affinity. It is primarily expressed on neutrophils and mediates their chemotaxis and activation during inflammation. CXCR1 plays a crucial role in the inflammatory response and is implicated in various diseases, including cancer, autoimmune disorders, and acute respiratory distress syndrome. It is a potential therapeutic target for modulating inflammation and tumor microenvironment.
- Other names
- Interleukin 8 receptor, alphaIL8RACD181
02
Mechanism of action
CXCR1 antagonists/blockers inhibit the binding of IL-8/CXCL8 and CXCL6 to the receptor, thereby preventing downstream signaling and reducing neutrophil chemotaxis and activation.
03
Biological functions
Signal transductionNeutrophil chemotaxisNeutrophil activationImmune responseInflammation regulationCell migration
04
Disease associations
CancerInflammationAutoimmune diseasesAcute respiratory distress syndrome (ARDS)Acute myeloid leukemia (AML)
05
Safety considerations
Potential for immunosuppressionOff-target effects due to structural similarity with other chemokine receptors
06
Biomarkers
CXCR1 expression levels in tumorsCXCR1 expression on neutrophilsIL-8/CXCL8 levels
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