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Target intelligence / Profile preview
C-X-C motif chemokine receptor 3 (CXCR3)
- Target
- CXCR3
- Molecular classification
- G protein-coupled receptor, Chemokine receptor
01
Overview
C-X-C motif chemokine receptor 3 (CXCR3) is a G protein-coupled receptor that plays a central role in immune cell trafficking, inflammation, and disease pathophysiology. It is predominantly expressed on activated T lymphocytes and mediates migration of Th1-polarized effector T cells to sites of inflammation. Dysregulation or altered expression/function has been implicated in autoimmune diseases, chronic inflammatory disorders, cancer progression/metastasis, and skin diseases.
- Other names
- G protein-coupled receptor 9GPR9CD183
02
Mechanism of action
CXCR3 antagonists can block ligand binding and downstream signaling.
03
Biological functions
Immune cell traffickingImmune polarizationSignal transductionRegulation of intracellular Ca²⁺ levelsActivation of PI3K pathwayActivation of MAPK pathway
04
Disease associations
Autoimmune diseasesChronic inflammatory disordersCancer progressionCancer metastasisSkin diseases
05
Safety considerations
Potential for immunosuppressionOff-target effects on other chemokine receptorsContext-dependent pro- or anti-tumorigenic effects
06
Biomarkers
CXCR3 expression levels in T cellsCXCL9, CXCL10, and CXCL11 levels in serum or tissue
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