Target intelligence / Profile preview

C-X-C motif chemokine receptor 4 (CXCR4)

Target: CXCR4
Molecular classification: G protein-coupled receptor

Overview

CXCR4 is a G protein-coupled receptor that binds to CXCL12 (SDF-1) and plays diverse roles in the immune system, hematopoiesis, development, and viral infection. It is involved in chemotaxis, cell migration, and acts as a coreceptor for HIV entry. Dysregulation is implicated in diseases such as WHIM syndrome and cancer metastasis.

Other names: FusinCD184

Mechanism of action

Small-molecule antagonist; blocks SDF-1 binding

Biological functions

Signal transductionChemotaxisHematopoiesisNeuronal guidanceImmune responseCell migrationCell proliferationSurvival/apoptosisGene transcription

Disease associations

WHIM syndromeMacroglobulinemiaCancerHIV/AIDS

Interacting drugs

Plerixafor

2 more in the full profile.

Beyond the preview

Go deeper on C-X-C motif chemokine receptor 4 (CXCR4).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on C-X-C motif chemokine receptor 4 (CXCR4).

Explore the full profile