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C1RL antisense RNA 1 (C1RL-AS1)
- Target
- C1RL-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Other
01
Overview
C1RL antisense RNA 1 (C1RL-AS1) is a long non-coding RNA gene located on chromosome 12p13.31 and is primarily expressed in mesenchymal-derived cell types[4][5]. It does not code for a protein but functions in the regulation of gene expression, particularly in the context of cancer biology. Recent research implicates C1RL-AS1 as a regulator of proliferation, migration, and apoptosis in gastric cancer cells, acting via the AKT/β-catenin/c-Myc signaling axis. Mechanistically, it may function as a competing endogenous RNA (ceRNA), modulating the availability of microRNAs and influencing the expression of cancer-associated genes[2][3]. High expression of C1RL-AS1 correlates with more aggressive cancer phenotypes and poorer prognosis, underscoring its potential as a biomarker and experimental therapeutic target. However, no drugs are known to directly target C1RL-AS1, and its role as a therapy target remains investigational.
- Other names
- MATL2963ABC12-49244600F4.3C1RL-AS1C1RL antisense RNA 1 (non-protein coding)
02
Mechanism of action
Not applicable; as a non-coding RNA, no direct small molecule or biologic targeting is known
03
Biological functions
Regulation of cell proliferationRegulation of apoptosisRegulation of cell migrationRegulation of epithelial-mesenchymal transition (EMT)Modulation of AKT/β-catenin/c-Myc signaling pathwayCompeting endogenous RNA (ceRNA) activity
04
Disease associations
Cancer (notably gastric cancer, possible broader oncogenic role)
05
Safety considerations
Not known; therapeutic manipulation of lncRNAs in humans is largely experimental
06
Biomarkers
High expression may serve as a prognostic biomarker for poor outcome in gastric cancer
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