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Target intelligence / Profile preview
C5a Anaphylatoxin Chemotactic Receptor (C5AR1)
- Target
- C5AR1
- Molecular classification
- G protein-coupled receptor
01
Overview
C5AR1 is a G protein-coupled receptor (GPCR) that serves as the primary receptor for the complement anaphylatoxin C5a. It plays a central role in mediating inflammatory and immune responses. Upon binding to C5a, it stimulates chemotaxis of phagocytic cells, induces granule enzyme release, and triggers superoxide anion production. Dysregulated activation of C5AR1 contributes to pathological inflammation. Antagonists are being developed for anti-inflammatory therapies.
- Other names
- CD88Complement component 5a receptor 1C5aR
02
Mechanism of action
Orthosteric and allosteric antagonism
03
Biological functions
ChemotaxisEnzyme releaseOxidative burstUpregulation of adhesion moleculesModulation of inflammatory responsesRegulation of epithelial cell proliferationImmune responseSignal transduction
04
Disease associations
InflammationSepsisAutoimmunityCancerObesityDevelopment
05
Safety considerations
Excessive or dysregulated activation contributes to pathological inflammation
06
Biomarkers
CD88 expression levels
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