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Target intelligence / Profile preview
C5a anaphylatoxin chemotactic receptor 1 (C5AR1)
- Target
- C5AR1
- Molecular classification
- G protein-coupled receptor
01
Overview
C5a anaphylatoxin chemotactic receptor 1 (C5AR1), also known as CD88, is a G protein-coupled receptor (GPCR) that serves as the primary receptor for complement component 5a (C5a), a potent pro-inflammatory peptide generated during activation of the complement system. It plays a central role in mediating immune and inflammatory responses. Activation leads to chemotaxis, cytokine release and modulation of cellular processes. Dysregulation is implicated in various diseases.
- Other names
- CD88C5aRC5R1
02
Mechanism of action
Agonists stimulate C5AR1, activating G proteins and downstream signaling pathways (e.g., calcium mobilization, ERK1/2 phosphorylation). Antagonists block C5a binding and subsequent receptor activation.
03
Biological functions
Immune cell chemotaxisInflammatory response modulationSignal transduction
04
Disease associations
SepsisAsthmaCancer progression/metastasisNeuropathic painObesityCardiac regeneration
05
Safety considerations
Overactivation can lead to excessive inflammation and tissue damage.Targeted inhibition may compromise protective immunity.
06
Interacting drugs
Paclitaxel
2 more in the full profile.
07
Biomarkers
C5AR1 expression levels in cancer cells (e.g., non-small cell lung cancer)
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