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Target intelligence / Profile preview
CACNA1C intronic transcript 1 (CACNA1C-IT1)
- Target
- CACNA1C-IT1
- Molecular classification
- Long non-coding RNA (lncRNA)
01
Overview
CACNA1C intronic transcript 1 (CACNA1C-IT1) is a non-coding RNA transcribed from an intronic region of the CACNA1C gene. Unlike the protein-coding CACNA1C gene, which encodes the pore-forming alpha-1C subunit of the L-type voltage-gated calcium channel involved in cardiac and neuronal physiology, CACNA1C-IT1 does not translate into a protein product. Its precise biological function is unclear, and there is currently no evidence that it is considered a therapeutic target for drug discovery or clinical interventions[5]. Key distinction: CACNA1C-IT1 is a transcript at the CACNA1C locus but is not the same as the protein-coding CACNA1C gene, which encodes a critical voltage-gated calcium channel subunit with well-defined biomedical relevance[1][2][3][4]. All major drug and gene target databases recognize CACNA1C as a protein-coding gene, not CACNA1C-IT1. If you are interested in the protein product of CACNA1C (CaV1.2), which is a bona fide therapeutic target, please specify accordingly.
- Other names
- CACNA1C-IT1
02
Mechanism of action
Not applicable; no defined mechanism as a drug target.
03
Biological functions
Not clearly characterized in the literature as of current data; presumed regulatory lncRNA.
04
Disease associations
No direct, validated disease role documented; contrast with CACNA1C protein, which is implicated in neuropsychiatric and cardiac disorders[1][2][3][4].
05
Safety considerations
Not applicable, as this is not a druggable protein or receptor.
06
Interacting drugs
None reported.
07
Biomarkers
Not reported; no evidence for established biomarker status.
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