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Target intelligence / Profile preview
Cadherin-1 (CDH1)
- Target
- CDH1
- Molecular classification
- Cadherins, Cell surface glycoprotein
01
Overview
Cadherin-1 (CDH1), also known as E-cadherin, is a calcium-dependent cell-cell adhesion glycoprotein primarily expressed in epithelial tissues. It is essential for maintaining proper cell-cell adhesion, tissue architecture, and cellular polarity. E-cadherin acts as a tumor suppressor, and its loss or mutation promotes cancer metastasis. It mediates homophilic interactions, crucial for epithelial integrity and suppressing invasion/metastasis. Interactions with catenins like p120 are essential for cell junction stability and signaling.
- Other names
- E-cadherinEpithelial cadherinCD324
02
Biological functions
Cell-cell adhesionSignal transductionRegulation of gene expressionMaintenance of epithelial integrityTumor suppression
03
Disease associations
CancerHereditary diffuse gastric cancerLobular breast cancerColorectal cancerThyroid cancerOvarian cancer
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