Cadherin-1 messenger RNA (CDH1 mRNA) (CDH1 mRNA)

Cadherin-1 (CDH1) mRNA is the transcript encoding E-cadherin, a critical transmembrane protein that mediates calcium-dependent cell-cell adhesion and maintains epithelial tissue architecture [1, 2]. The loss of CDH1 mRNA expression is a primary driver of the epithelial-mesenchymal transition (EMT), a process where cells lose their polar and adhesive properties to gain migratory and invasive characteristics, leading to cancer progression [3, 5]. This downregulation is frequently observed in Hereditary Diffuse Gastric Cancer (HDGC) and invasive lobular breast cancer, often resulting from genetic mutations or epigenetic silencing of the CDH1 promoter [1, 4]. As a therapeutic target, CDH1 mRNA is primarily addressed through strategies aimed at restoring its expression, such as the use of histone deacetylase (HDAC) inhibitors or DNA methyltransferase (DNMT) inhibitors to reverse epigenetic repression [3]. Additionally, CDH1 mRNA levels serve as a crucial biomarker for identifying tumors susceptible to synthetic lethality approaches, which target specific vulnerabilities in E-cadherin-deficient cells [4]. Emerging research also explores the use of mRNA-based delivery systems to reintroduce functional CDH1 transcripts into deficient tumor cells to suppress metastasis [5]. Monitoring CDH1 mRNA expression is therefore essential for both diagnostic stratification and the evaluation of therapeutic responses in epithelial-derived malignancies [2, 3]. Sources: [1] NCBI Gene (https://www.ncbi.nlm.nih.gov/gene/999) [2] UniProt (https://www.uniprot.org/uniprotkb/P12830/entry) [3] Carneiro et al., PubMed (https://pubmed.ncbi.nlm.nih.gov/24501514/) [4] Bajrami et al., Nature Communications (https://www.nature.com/articles/s41467-018-06031-0) [5] StatPearls, E-Cadherin (https://www.ncbi.nlm.nih.gov/books/NBK545259/)

Other names

E-cadherin mRNACDH1 transcriptUvomorulin mRNACalcium-dependent adhesion protein, epithelial mRNAArc-1 mRNA

Epigenetic reactivation of the CDH1 promoter to increase mRNA transcription or mRNA replacement therapy to restore protein function.