Cadherin 1 messenger RNA 3′ untranslated region (CDH1 mRNA 3′UTR) (CDH1 3′UTR)

The Cadherin 1 (CDH1) mRNA 3′ untranslated region (3′UTR) is a critical regulatory segment of the messenger RNA encoding E-cadherin, a pivotal cell-cell adhesion protein and tumor suppressor (NIH, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705877/). This region is unusually long, spanning approximately 2.2 kb, and serves as a hub for post-transcriptional regulation by various microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) (NIH, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705877/). Specifically, miRNAs such as miR-23a, miR-217, and miR-92a-3p bind to the CDH1 3′UTR to downregulate its expression, thereby promoting epithelial-mesenchymal transition (EMT), tumor invasion, and metastasis in cancers like gastric, prostate, and neuroblastoma (Semanticscholar, https://www.semanticscholar.org/paper/miR-23a-promotes-neuroblastoma-cell-migration-and-by-Guo-Li/7e7e...; MDPI, https://www.mdpi.com/2072-6694/11/4/481). Therapeutic strategies targeting this region include the use of miRNA inhibitors (anti-miRs) or lncRNA sponges (e.g., UCA1) to stabilize CDH1 mRNA and restore E-cadherin levels (Ovid, https://journals.lww.com/oncology-times/fulltext/2019/11050/lncrna_uca1_maintains_e_cadherin_levels_in.10.aspx). Furthermore, single nucleotide polymorphisms (SNPs) within the 3′UTR, such as rs1801026, have been identified as biomarkers for increased risk of gastric lymphoma and other malignancies due to their impact on mRNA stability (NIH, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705877/). Targeting the CDH1 3′UTR represents a novel approach in precision oncology to counteract the loss of cell adhesion and suppress metastatic progression.

Other names

E-cadherin mRNA 3′UTRCDH1 3-prime untranslated regionCDH1 3′ untranslated regionCadherin-1 3′UTR

The CDH1 3′UTR is targeted by oncogenic microRNAs (oncomiRs) that induce mRNA degradation or translational repression; therapeutic strategies utilize antisense oligonucleotides (ASOs) or miRNA inhibitors (anti-miRs) to competitively bind these sites, thereby stabilizing the mRNA and restoring E-cadherin protein levels (Semanticscholar, https://www.semanticscholar.org/paper/miR-23a-promotes-neuroblastoma-cell-migration-and-by-Guo-Li/7e7e...; Ovid, https://journals.lww.com/oncology-times/fulltext/2019/11050/lncrna_uca1_maintains_e_cadherin_levels_in.10.aspx).