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Cadherin-15 (CDH15)
- Target
- CDH15
- Molecular classification
- Cell adhesion molecule, Calcium-dependent glycoprotein, Type I classical cadherin, Transmembrane protein
01
Overview
Cadherin-15 is a transmembrane glycoprotein member of the cadherin superfamily, mediating calcium-dependent homophilic cell-cell adhesion, predominantly in muscle cells. The molecule has five extracellular cadherin domains, a single transmembrane domain, and a conserved cytoplasmic tail. Expression is strongest during muscle cell differentiation (myogenesis) and is essential for regulating terminal differentiation in muscle tissue. CDH15's loss or mutation is associated with intellectual disability syndromes, and it participates in cell junction organization and ERK signaling. While it is considered an important receptor-like adhesion molecule, no direct pharmacological modulators are clinically approved.
- Other names
- Cadherin-15CDH15MCADMRD3CDH3CDH14cadherin 15M-cadherinmuscle cadherinCDHM
02
Biological functions
Cell-cell adhesionCalcium ion bindingMyogenesis (muscle development and differentiation)Morphogenesis
03
Disease associations
Intellectual developmental disorder (Autosomal Dominant 3)Non-syndromic intellectual disabilityPotential biomarker in muscle differentiation disorders (inferred, not confirmed)Other roles in cancer and cell proliferation are suspected but not conclusively established
04
Safety considerations
Targeting cell adhesion proteins may disturb tissue integrity or normal morphogenesisPotential risk of muscle development defects if inhibited (inferred from biological function)
05
Biomarkers
CDH15 itself can serve as a marker for muscle differentiation
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