Cadherin-17 ()

Cadherin-17 Overview

Cadherin-17 (CDH17), also known as Liver-Intestine cadherin (LI-cadherin), is a calcium-dependent, type I transmembrane glycoprotein belonging to the cadherin superfamily. It is primarily expressed in the gastrointestinal tract, pancreatic ducts and liver, where it mediates homotypic cell-cell adhesion and functions as an intestinal proton-dependent peptide transporter. CDH17 is aberrantly overexpressed in several cancers, notably gastric cancer, where it acts as an oncogenic biomarker due to its involvement in tumor growth regulation via apoptosis signaling pathways. It binds via homophilic interactions and has a different adhesion mechanism than classical cadherins.

Mechanism of Action

Biological Functions

Safety Considerations

Associated Biomarkers