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Target intelligence / Profile preview
Cadherin 17 (CDH17)
- Target
- CDH17
- Molecular classification
- Cadherin, Cell adhesion molecule, Transporter
01
Overview
Cadherin 17 (CDH17) is a calcium-dependent cell adhesion molecule and intestinal proton-dependent peptide transporter primarily expressed in the gastrointestinal tract and pancreatic ducts. It plays a crucial role in tissue structure and morphogenesis. Aberrant expression is observed in several gastrointestinal malignancies, including hepatocellular carcinoma, stomach cancer, colorectal cancer, and pancreatic cancer, making it an attractive therapeutic target.
- Other names
- LI-cadherin
02
Mechanism of action
Inhibition of CDH17 can inhibit tumor growth, suppress Wnt signaling pathway activity, and activate tumor suppressor genes.
03
Biological functions
Cell adhesionPeptide transportTissue structure maintenanceMorphogenesisRegulation of apoptosis signalingWnt signaling modulation
04
Disease associations
CancerHepatocellular carcinomaStomach cancerColorectal cancerPancreatic cancer
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