Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
N-cadherin
- Molecular classification
- Classical type I cadherin, Cell adhesion molecule
01
Overview
N-cadherin, also known as Neural cadherin or Cadherin-2, is a classical type I cadherin cell adhesion molecule that mediates homophilic cell–cell adhesion. It plays critical roles in maintaining tissue integrity, regulating cellular behaviors such as migration, and is implicated in cancer metastasis and other diseases. N-cadherin interacts with catenins intracellularly and participates in several key signaling pathways, including Rap1, Wnt, Hippo, Focal Adhesion, and Adherens junction pathways.
- Other names
- Neural cadherinCadherin-2CDH2CD325
02
Mechanism of action
Inhibition of N-cadherin mediated cell adhesion; modulation of downstream signaling pathways
03
Biological functions
Cell-cell adhesionTissue morphogenesisCell migrationRegulation of cell signalingMaintenance of tissue architecture
04
Disease associations
Cancer progression/metastasisCardiac diseasesNeurological development disordersGliomas/Glioblastoma
05
Safety considerations
Potential for off-target effects on normal tissues expressing N-cadherinComplexity of modulating cell adhesion without disrupting essential physiological processes
06
Biomarkers
N-cadherin expression level in tumors
Beyond the preview
Go deeper on N-cadherin.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on N-cadherin.