Cadherin-22 (CDH22)

Cadherin-22 (CDH22) is a member of the cadherin superfamily of calcium-dependent cell adhesion proteins, characterized by five extracellular cadherin repeats and a conserved cytoplasmic tail[2][8]. It is predominantly expressed in the brain and neuroendocrine tissues, where it is believed to mediate homophilic cell-cell adhesion and play an important role in tissue morphogenesis, compartmentalization, and maintenance—especially in the brain and pituitary gland[2][3][8]. CDH22 is implicated in cancer pathophysiology, with evidence showing its promoter hypermethylation and expression downregulation in breast cancer, suggesting possible tumor-suppressive characteristics[6]. No known direct drug interactions or approved therapeutic targeting have been documented; its principal recognized function is in morphogenesis and tissue organization[8].

Other names

C20orf25PB-cadherindJ998H6.1pituitary and brain cadherincadherin 22, type 2cadherin-like 22ortholog of rat PB-cadherin