Cadherin-23 (CDH23)

Cadherin-23 is a type I transmembrane protein belonging to the cadherin superfamily, characterized by a large extracellular domain with 27 cadherin repeats and a cytoplasmic tail. It is a critical component of hair-cell tip links in the inner ear, where it mediates calcium-dependent cell–cell adhesion essential for mechanotransduction—the process by which hair cells convert mechanical sound vibrations into neural signals. The protein is also found in the retina, where it is required for normal photoreceptor cell function. Mutations in the CDH23 gene lead to non-syndromic prelingual hearing loss (DFNB12) and syndromic forms of deafness, particularly Usher syndrome type 1D, a leading cause of inherited deaf-blindness[2][3][4][5].

Other names

KIAA1774KIAA1812UNQ1894/PRO4340CDHR23PITA5USH1Dcadherin-like 23cadherin-related family member 23otocadherinOtocadherin

Not applicable; CDH23 is not a known direct drug target[5]