Target intelligence / Profile preview

Cadherin 3 (CDH3)

Target: CDH3
Molecular classification: Classical cadherin, Cadherin superfamily, Glycoprotein

Overview

Cadherin 3 (CDH3), also known as P-cadherin, is a classical cadherin protein involved in calcium-dependent cell-cell adhesion. It plays an essential role in maintaining tissue architecture and is implicated in various cancers. Abnormal expression patterns make it an emerging target for cancer immunotherapies.

Other names: P-cadherinPCADCDHPHJMD

Mechanism of action

Emerging target for cancer immunotherapies; evaluation ongoing for its potential use against various carcinomas including those affecting lymph nodes via metastasis regulation.

Biological functions

Calcium-dependent cell-cell adhesionTissue architecture maintenanceCell sortingCell organizationHomophilic interactions

Disease associations

Congenital hypotrichosis with juvenile macular dystrophy (HJMD)Ectodermal dysplasia with ectrodactyly and macular dystrophy (EEM)Cancer (Breast, Prostate, Cervical)

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