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Vascular endothelial cadherin (VE-cadherin)
- Target
- VE-cadherin
- Molecular classification
- Classical Cadherin Superfamily, Calcium-dependent cell–cell adhesion glycoprotein
01
Overview
VE-cadherin, also known as Cadherin-5 or CD144, is an endothelium-specific adhesion protein located at junctions between endothelial cells (ECs), playing a critical role in maintaining vascular integrity and regulating cell-cell adhesion within blood vessels. It is indispensable for maintaining cohesion and organization of intercellular junctions in endothelium and regulating vascular permeability. It has been studied as a potential therapeutic target for modulating vascular permeability in disease contexts such as cancer metastasis or inflammatory disorders.
- Other names
- Cadherin-5CD144
02
Mechanism of action
Antibody-mediated inhibition of VE-cadherin
03
Biological functions
Cell-cell adhesionRegulation of vascular permeabilityMaintenance of vascular integrityModulation of cell proliferationRegulation of leukocyte extravasationRegulation of apoptosisEmbryonic vascular development
04
Disease associations
CancerInflammationVascular development defectsTumor angiogenesisInflammatory disorders
05
Safety considerations
Increased vascular leakageEdemaHemorrhage
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