Target intelligence / Profile preview

Cadherin-6 (CDH6)

Target: CDH6
Molecular classification: Type II classical cadherin, Transmembrane glycoprotein

Overview

Cadherin-6 (CDH6) is a calcium-dependent cell adhesion protein that belongs to the cadherin superfamily. It mediates homophilic cell-cell adhesion and plays critical roles in tissue morphogenesis and differentiation, particularly in the kidney where it inhibits tubulogenesis. Dysregulation of CDH6 has been linked to diseases such as cancer and craniofacial-deafness-hand syndrome.

Other names: CDH6 proteinK-cadherin

Biological functions

Cell-cell adhesionRegulation of tubulogenesisCell migrationCell junction organization

Disease associations

CancerCraniofacial-deafness-hand syndromeRenal cell carcinoma

Safety considerations

Dysregulation associated with tumor growth and metastasis

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