Cadherin EGF LAG seven-pass G-type receptor 2 (CELSR2)

Cadherin EGF LAG seven-pass G-type receptor 2 (CELSR2) is a large membrane protein with nine cadherin ectodomains, several EGF-like domains, and a seven-pass transmembrane region typical of adhesion GPCRs. It mediates essential processes such as planar cell polarity, tissue morphogenesis, neural wiring, and cilia organization in vertebrates. As part of the noncanonical Wnt/PCP signaling pathway, CELSR2 organizes and stabilizes cell–cell contacts, regulates migration and axon guidance of neurons, and may impact lipid metabolism and cardiovascular risk. Alterations in CELSR2 function or expression are associated with defects in embryonic development, adult synaptic integrity, dyslipidemia, and possibly other diseases. Research continues to elucidate its therapeutic potential and mechanistic roles[1][2][3][5].

Other names

Cadherin family member 10Adhesion G protein-coupled receptor C2Flamingo1Multiple EGF-like domains protein 3CDHF10MEGF3EGFL2KIAA0279EGF-like protein 2Epidermal growth factor-like protein 2Flamingo homolog 3

Not applicable for approved drugs. Mechanistically, therapeutic targeting would likely involve modulation of cell adhesion and PCP signaling.