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CADM3 antisense RNA 1 (CADM3-AS1)

Target: CADM3-AS1
Molecular classification: Long non-coding RNA (lncRNA), Antisense RNA

Overview

CADM3 antisense RNA 1 (CADM3-AS1) is a human long non-coding RNA gene transcribed from the opposite (antisense) strand of the cell adhesion molecule 3 (CADM3) locus on chromosome 1. Classified as an antisense lncRNA, CADM3-AS1 has multiple transcripts and does not encode a protein[1][3]. Like other antisense lncRNAs, it is implicated in regulating expression of adjacent or overlapping genes, modulating gene activity via transcriptional interference, and potentially influencing chromatin structure or transcription factor binding[2]. CADM3-AS1 is downregulated in several human cancers, including lung adenocarcinoma and cervical squamous cell carcinoma, where its high expression is associated with favorable prognosis and tumor suppression, making it a useful biomarker for disease progression[3][7]. While its precise mechanistic function remains under investigation, CADM3-AS1 is currently being explored for its biological and clinical relevance in oncology and gene regulation[3][7][1].

Other names: CTA-134P22.2CADM3-AS1

Biological functions

Regulation of gene expressionPotential involvement in tumor suppression

Disease associations

Cancer (downregulated in several cancers, implicated as a tumor suppressor and prognostic biomarker in lung adenocarcinoma and cervical squamous cell carcinoma)Other (possible broad role in gene regulation; more study required)

Biomarkers

Prognostic biomarker in lung adenocarcinoma and cervical cancerExpression level as a marker for tumor suppression and clinical outcomes

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