Calcineurin B homologous protein 1 (CHP1)

Calcineurin B homologous protein 1 (CHP1) is a ubiquitously expressed, calcium-binding EF-hand protein that functions primarily as an obligate regulatory cofactor of sodium/hydrogen exchangers, especially NHE1. It is structurally related to calcineurin B and calmodulin and plays important roles in Na+/H+ exchange, membrane trafficking, vesicle targeting and fusion, and cellular pH regulation. CHP1 also participates in the inhibition of the calcineurin/NFAT pathway and gene transcription regulation, and influences processes such as axon maintenance and neurodevelopment. Disruption of CHP1 function may lead to pH dysregulation and neurological disease, reflecting its critical involvement in ion homeostasis and membrane protein trafficking[1][2][3][4].

Other names

Calcineurin like EF-hand protein 1CHPSid470pSLC9A1BPp22p24Calcineurin B-like proteinCalcium-binding protein CHPCalcium-binding protein p22EF-hand calcium-binding domain-containing protein p22Calcineurin homologous proteinSPAX9

Inhibition of sodium/proton exchange (e.g., cariporide blocks NHE1 activity by preventing conformational change in the NHE1-CHP1 complex)