Calcineurin-binding protein cabin-1 (CABIN1)

Calcineurin-binding protein cabin-1 (CABIN1) is a nuclear protein encoded by the CABIN1 gene, which specifically binds to the activated form of the protein phosphatase calcineurin and inhibits its signal transduction, especially in the T-cell receptor pathway[1][2][5]. CABIN1 contains a leucine zipper domain and PEST motifs associated with protein-protein interactions and degradation, respectively[2]. It acts as a negative regulator of T-cell signaling, and has additional roles in regulating transcription factors such as MEF2 and p53, chromatin assembly, and cellular apoptosis[1][2][4][6]. CABIN1 associates with diseases involving immune dysregulation and neuronal development[2][4][6].\n\nNote: No drugs are currently known to specifically target CABIN1 for therapeutic modulation; clinically relevant immunosuppressants inhibit calcineurin directly, not CABIN1[3]. CABIN1 is a research target with potential implications in immune diseases, cancer, and neurological function.

Other names

CABIN1CAINPPP3INKIAA0330KB-318B8.7calcineurin inhibitorcalcineurin binding protein 1calcineurin-binding protein cabin-1

Theoretically, a drug could block CABIN1/calcineurin binding. It is involved in the inhibition of calcineurin-mediated dephosphorylation pathways.