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Calcineurin Phosphatase (PP2B)
- Target
- PP2B
- Molecular classification
- Enzyme, Serine/threonine protein phosphatase
01
Overview
Calcineurin phosphatase is a calcium and calmodulin-dependent serine/threonine protein phosphatase that plays a central role in calcium-mediated signal transduction pathways. It is best known for its function in activating T cells of the immune system. Calcineurin is a heterodimer composed of a catalytic subunit (calcineurin A) and a regulatory subunit (calcineurin B). It is activated by an increase in intracellular Ca²⁺ concentration and binding of calmodulin. Calcineurin regulates numerous cellular processes through dephosphorylation events and is potently inhibited by immunosuppressive drugs such as cyclosporin A and tacrolimus (FK506).
- Other names
- Protein phosphatase 3PPP3CaN
02
Mechanism of action
Inhibition of calcineurin phosphatase activity by drug-immunophilin complex
03
Biological functions
Signal transductionImmune responseNeural signalingMuscle developmentCalcium signaling regulation
04
Disease associations
Autoimmune diseasesTransplant rejectionCardiac hypertrophyNeurodegenerative diseases
05
Safety considerations
ImmunosuppressionNephrotoxicityNeurotoxicityIncreased risk of infectionIncreased risk of malignancy
06
Interacting drugs
Cyclosporin A
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