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Calcineurin subunit A alpha isoform (CnAα)
- Target
- CnAα
- Molecular classification
- Enzyme, Serine/threonine protein phosphatase
01
Overview
Calcineurin subunit A alpha isoform is the catalytic component of calcineurin, a calcium and calmodulin-dependent serine/threonine protein phosphatase (PPP3CA). Calcineurin plays a central role in transducing calcium signals to regulate diverse physiological processes, especially within the immune, cardiovascular, and nervous systems. It dephosphorylates members of the nuclear factor of activated T-cells (NFAT) family and regulates cardiac hypertrophy via NFAT signaling pathways in cardiomyocytes. It is a target for immunosuppressive drugs.
- Other names
- Protein phosphatase 3 catalytic subunit alphaPPP3CACalcineurin A alphaPP2B catalytic subunit alpha isoform
02
Mechanism of action
Inhibition of calcineurin phosphatase activity
03
Biological functions
Signal transductionImmune responseCardiac functionNeuronal signaling
04
Disease associations
Cardiac hypertrophyHeart failureNeurodegenerative diseaseAutoimmune diseases
05
Safety considerations
Off-target effects due to broad tissue distributionImmunosuppression-related adverse events
06
Interacting drugs
Cyclosporin A
1 more in the full profile.
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