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Target intelligence / Profile preview
Calcineurin Subunit B Type 1 (CNB1)
- Target
- CNB1
- Molecular classification
- EF-hand domain-containing protein, Regulatory protein, Enzyme subunit
01
Overview
Calcineurin subunit B type 1 is the regulatory subunit of calcineurin, a calcium-dependent, calmodulin-stimulated serine/threonine protein phosphatase. It contains multiple EF-hand domains that bind Ca²⁺ ions, which are essential for activation of calcineurin in response to intracellular calcium signals. It plays critical roles in immune cell activation and regulates physiological processes in cardiovascular and nervous systems. Inhibitors like cyclosporin A and tacrolimus are used as immunosuppressants.
- Other names
- Protein Phosphatase 2B Regulatory Subunit 1PPP3R1
02
Mechanism of action
Inhibition of calcineurin phosphatase activity
03
Biological functions
Calcium ion bindingSignal transductionRegulation of phosphatase activityImmune signaling (NFAT pathway)Cardiovascular regulation
04
Disease associations
Alzheimer's diseaseAutoimmune diseasesTransplant rejection
05
Safety considerations
ImmunosuppressionAdverse effects due to widespread expression and function when inhibited
06
Interacting drugs
Cyclosporin A (CsA)
1 more in the full profile.
07
Biomarkers
PPP3R1 polymorphisms (e.g., rs1868402) for Alzheimer's disease progression
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