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Target intelligence / Profile preview
Calcium-Activated Chloride Channel Protein
- Molecular classification
- Ion channel, Ligand-gated ion channel, Anoctamin family, TMEM16 family, Chloride channel
01
Overview
Calcium-activated chloride channels (CaCCs) are a group of ligand-gated ion channels that mediate the flow of chloride ions across cell membranes in response to increases in intracellular calcium levels. These channels play essential roles in various physiological processes, including epithelial secretion, sensory transduction, smooth muscle contraction, neuronal excitability, and fluid homeostasis. TMEM16A (ANO1) and TMEM16B (ANO2) are key members of the TMEM16 (anoctamin) family functioning as CaCCs. They are promising therapeutic targets for conditions characterized by abnormal mucus production or impaired motility, ranging from asthma to cancer.
- Other names
- CaCCTMEM16AANO1ANO2TMEM16B
02
Mechanism of action
Channel blockade; Channel activation
03
Biological functions
Electrolyte/fluid secretionSensory signal transductionSmooth muscle contractionNeuronal excitabilityFluid homeostasis
04
Disease associations
Cystic fibrosisAsthmaHypertensionTumorigenesisAbnormal gut motility
05
Safety considerations
Potential for off-target effects due to widespread expressionModulation of multiple physiological processes
06
Interacting drugs
Niflumic acid (NFA)
2 more in the full profile.
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