Calcium-activated chloride channel regulator 2 (CLCA2)

Calcium-activated chloride channel regulator 2 (CLCA2) is a type I transmembrane protein and member of the CLCA family, widely recognized as a regulator rather than a subunit of calcium-activated chloride channels. It possesses a self-cleaving zinc metalloprotease domain and modulates calcium-dependent chloride currents principally via interaction with signaling proteins STIM-1, ORAI-1, and indirectly TMEM16A. CLCA2 plays a critical role in epithelial cell physiology, including cell adhesion, differentiation, and apoptosis, and acts as a tumor suppressor, with markedly reduced expression in a range of adenocarcinomas and cervical carcinoma. It is induced by cellular stress and is essential for proper calcium signaling and chloride channel function in epithelia, and loss of CLCA2 is associated with increased metastatic and proliferative capacity in tumor cells.

Other names

Calcium-activated chloride channel regulator 2, 109 kDa formCalcium-activated chloride channel regulator 2, 35 kDa formCACC3hCLCA2CaCC-3CLCRG2Calcium-activated chloride channel family member 2Calcium-activated chloride channel protein 3CACCchloride channel regulatorcalcium-activated chloride channel protein 3CLCA family member 2chloride channel, calcium activated, family member 2

For investigational approaches: Tumor suppression via inhibition of EMT and cancer cell proliferation, through modulation of the p38/JNK/ERK pathway and calcium signaling. Modulation of intracellular calcium levels and chloride current indirectly by interaction with STIM-1 and ORAI-1 and enhancement of TMEM16A activity.