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Target intelligence / Profile preview
Calcium-activated potassium channel (KCa channel)
- Target
- KCa channel
- Molecular classification
- Ion channel, Potassium channel
01
Overview
Calcium-activated potassium channels (KCa channels) are a family of potassium ion channels that open in response to increases in intracellular calcium concentration. Their activation leads to the efflux of potassium ions, resulting in membrane hyperpolarization and regulation of cellular excitability. These channels play crucial roles in neuronal signaling, muscle contraction, vascular tone, and various physiological processes. There are three main subtypes: Large (BK), Intermediate (IK), and Small (SK), each with distinct tissue distributions and physiological functions.
- Other names
- BK channelSK channelIK channelSlo1KCNMA1SK4KCNN4SK1SK2SK3KCNN1KCNN2KCNN3
02
Mechanism of action
Blockade of potassium channel conductance, leading to membrane depolarization and altered cellular excitability.
03
Biological functions
Regulation of neuronal excitabilityRegulation of vascular toneRegulation of muscle contractionRegulation of action potential firingAfterhyperpolarizationCardioprotection
04
Disease associations
Cardiovascular diseasesHypertensionArrhythmiasNeurodegenerative diseasesFibrosis
05
Safety considerations
Potential for off-target effects due to the ubiquitous expression of KCa channels.Risk of altering cellular excitability in unintended tissues.
06
Interacting drugs
Charybdotoxin
2 more in the full profile.
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