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Calcium-activated potassium channel subfamily M alpha member 1 (None)
- Target
- None
- Molecular classification
- Ion channel, Potassium channel, Voltage-gated ion channel, Calcium-activated potassium channel
01
Overview
Calcium-activated potassium channel subfamily M alpha member 1 (KCNMA1) is a large conductance, voltage and calcium-activated potassium channel. It forms the pore-forming alpha subunit of BK channels, which regulate smooth muscle tone, neuronal excitability, and cochlear hair cell tuning. The channel is activated by membrane depolarization and increased intracellular calcium, leading to potassium efflux and cellular hyperpolarization. Mutations in KCNMA1 are associated with neurological disorders such as epilepsy and movement disorders.
- Other names
- BK channel alpha subunitKCa1.1MaxiK channelSlo1hSloKCNMA1big potassium channel alpha subunitmSLO1SLO/Slo homolog/Slo-alpha/Slo1/Slowpoke homolog/hSlo/K(VCA)alpha/BKCA alpha/KCNMA
02
Mechanism of action
Potassium channel blockade/activation leading to altered cellular excitability and muscle tone.
03
Biological functions
Regulation of smooth muscle toneModulation of neuronal excitabilityElectrical tuning of cochlear hair cellsRegulation of membrane potential
04
Disease associations
EpilepsyMovement disordersAlzheimer’s diseaseParoxysmal nonkinesigenic dyskinesia 3Transient episodes of muscle weakness
05
Safety considerations
Failed clinical trials (e.g., BMS-204352 in stroke)Potential for off-target effects due to widespread expression
06
Interacting drugs
Tetraethylammonium (TEA)
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