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Target intelligence / Profile preview
Calcium-activated potassium channel subunit alpha SLO-1 (SLO-1)
- Target
- SLO-1
- Molecular classification
- Ion channel, Potassium channel, Calcium-activated potassium channel
01
Overview
The calcium-activated potassium channel subunit alpha SLO-1 (BK, MaxiK, KCa1.1) is a large conductance potassium (K+) channel activated by both intracellular calcium ions (Ca2+) and membrane voltage. It plays a crucial role in coupling membrane excitability to Ca2+ signaling events, impacting muscle contraction, neurotransmitter release, hormone secretion, and auditory function. Functional channels are tetramers of alpha subunits, often associated with auxiliary beta-subunits. Mutations or dysfunctions are linked to several disorders including hypertension, epilepsy, and autism spectrum disorders.
- Other names
- BKMaxiKKCa1.1mSloBKCamSlo1
02
Biological functions
Regulation of neuronal excitabilityControl of smooth muscle tone/contractionModulation of neurotransmitter/hormone releaseSensory processing (hearing/audition)Potassium transport
03
Disease associations
HypertensionOveractive bladder/urinary incontinenceEpilepsy/idiopathic generalized epilepsy type 16Paroxysmal nonkinesigenic dyskinesia type 3Mental retardationAutism spectrum disordersLiang-Wang syndrome
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