Calcium and integrin-binding family member 3 (CIB3)

Calcium and integrin-binding family member 3 (CIB3) is a protein-coding gene involved in calcium ion binding and is thought to function as an auxiliary subunit of the sensory mechanoelectrical transduction (MET) channel in hair cells, regulating their localization and function. The precise physiological role remains unclear, but CIB3 may interact with integrins and DNA-dependent protein kinase catalytic subunit. Pathogenic variants have been associated with sensorineural deficits such as deafness and Usher syndrome type Ij; in model organisms, CIB3 deficiency leads to age-related balance and vestibular hair cell loss[1][3][4][6].

Other names

CIB3KIP3Kinase-interacting protein 3DNA-dependent protein kinase catalytic subunit-interacting protein 3