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Calcium and integrin-binding family member 4 (CIB4)
- Target
- CIB4
- Molecular classification
- Other (EF-hand calcium-binding protein; member of the CIB protein family)
01
Overview
Calcium and integrin-binding family member 4 (CIB4) is a small, EF-hand domain-containing protein that binds calcium and magnesium ions[3][4]. This binding increases its structural stability. It belongs to the CIB family, which also includes CIB1, CIB2, and CIB3, all of which are evolutionary conserved and share similar structures[2][3]. CIB4’s specific biological functions are not as well-studied as CIB1 or CIB2, which play established roles in integrin signaling, the cardiovascular system, and hearing[2]. Its main biochemical properties are ion binding and potential modulation of protein-protein interactions, especially with integrin family members. In other species, such as sheep, CIB4 interacts with proteins involved in calcium-mediated signal transduction, including calcineurin subunits and plasma membrane calcium pumps[1]. However, its expression is more limited, and there are no established disease associations or drug interactions for CIB4 in humans[2][4].
- Other names
- Calcium and integrin-binding family member 4CIB4KIP4
02
Biological functions
Calcium bindingMagnesium bindingStructural stabilization upon ion bindingPotential involvement in integrin signaling and protein-protein interactions (mainly inferred from family members, with unclear direct evidence for CIB4)
03
Disease associations
Other (The CIB family, especially CIB1 and CIB2, is implicated in cardiovascular disease, neurological disorders, cancer, and male infertility; however, explicit disease associations for CIB4 are not established)
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