Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Calcium-binding protein 2 (CaBP2)
- Target
- CaBP2
- Molecular classification
- Other (EF-hand calcium-binding protein), Calcium signaling protein
01
Overview
Calcium-binding protein 2 (CaBP2) is a member of the EF-hand calcium-binding protein family that regulates neuronal calcium signaling, especially in the auditory system[1][2][3]. It is structurally related to calmodulin but exhibits more brain- and retina-enriched expression patterns. CaBP2 is highly expressed in inner hair cells of the cochlea, where it helps to sustain synaptic transmission crucial for sound encoding by attenuating voltage- and calcium-dependent inactivation of L-type calcium channels, particularly CaV1.3[2][3]. Loss-of-function mutations in CABP2 cause autosomal recessive nonsyndromic hearing loss (DFNB93), but it is not currently a therapeutic drug target[3].
- Other names
- CABP2CaBP2DFNB93
02
Mechanism of action
Not therapeutically targeted; endogenous mechanism is inhibition of calcium channel inactivation, supporting sustained calcium influx and synaptic transmission[2][3].
03
Biological functions
Modulates calcium signalingRegulates inactivation of voltage-gated calcium channels (notably CaV1.3)Facilitates sustained neurotransmission at auditory inner hair cell ribbon synapses
04
Disease associations
Other (Hereditary deafness / Sensorineural hearing loss; specifically, DFNB93 nonsyndromic deafness)
05
Safety considerations
No information available; not a therapeutic target
06
Interacting drugs
None known
07
Biomarkers
None established for patient selection or efficacy monitoring
Beyond the preview
Go deeper on Calcium-binding protein 2 (CaBP2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Calcium-binding protein 2 (CaBP2).