Calcium-binding protein 4 (CABP4)

Calcium-binding protein 4 (CABP4) is a member of the calcium-binding protein family characterized by four EF-hand motifs[2]. It is highly expressed at photoreceptor synaptic terminals in the retina, where it modulates the activity of voltage-dependent calcium channels (notably Cav1.3 and Cav1.4), influencing calcium influx and neurotransmitter release[1][3][5]. Disruption of CABP4 impairs synaptic ribbon formation, leading to structural and functional abnormalities in the first retinal synapse and is associated with congenital stationary night blindness type 2B and cone-rod synaptic disorder[1][2][3]. CABP4 is also expressed in the brainstem and other regions, and mutations have been linked in rare instances to epilepsy[3]. While essential for visual and possibly auditory synaptic function, there are currently no known interacting drugs or direct therapeutic targeting of CABP4 reported[1][2][3][5].

Other names

CABP4CaBP4Calcium binding protein 4CSNB2BCRSD