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Target intelligence / Profile preview
Calcium-binding tyrosine phosphorylation-regulated protein (CABYR)
- Target
- CABYR
- Molecular classification
- Other (sperm-associated structural protein), does not belong to classic druggable classes like receptor, enzyme, transporter, or ion channel
01
Overview
Calcium-binding tyrosine phosphorylation-regulated protein (CABYR) is a testis-specific protein localized to the principal piece of the sperm flagellum, associated with the fibrous sheath. CABYR is expressed primarily in sperm and involved in sperm capacitation, a maturation process required for fertilization, through its roles in calcium binding (when phosphorylated) and as a structural component. Several transcript variants result in distinct protein isoforms, with some variants binding calcium only when phosphorylated. CABYR has also been found aberrantly expressed in various tumors, classifying it as a cancer/testis antigen and potential biomarker for certain cancers and male infertility, but it is not currently a therapeutic target.
- Other names
- CABYRaCABYRcCABYRc/dCABYReCBP86CT88FSP2FSP-2Cancer/testis antigen 88Fibrousheathin IIFibrousheathin-2Testis-specific calcium-binding protein CBP86calcium-binding protein 86testis tissue sperm-binding protein Li 84P
02
Biological functions
Calcium ion bindingRegulation of sperm motilityInvolvement in sperm capacitationAssociation with the fibrous sheath of the sperm flagellum
03
Disease associations
Cancer (aberrant expression in tumors, cancer/testis antigen)Male infertility (due to roles in sperm function and structure)
04
Safety considerations
no known safety concerns as no drugs target CABYRtestis-restricted proteins pose immunogenicity concerns as antigens in immunotherapy
05
Biomarkers
Potential cancer/testis antigen in certain cancersMarker of sperm maturation and capacitation/male fertility status
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