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Target intelligence / Profile preview
Calcium channel protein alpha 1C subunit (CaV₁.₂)
- Target
- CaV₁.₂
- Molecular classification
- Ion channel, Voltage-gated calcium channel, L-type calcium channel
01
Overview
The calcium channel protein alpha 1C subunit (CACNA1C) is a critical component of voltage-dependent L-type calcium channels. These channels mediate calcium influx upon membrane depolarization and are essential for numerous physiological processes, including cardiac action potentials, neurotransmitter release, and muscle contraction. Mutations in CACNA1C are associated with several disorders, including Timothy Syndrome and Long QT Syndrome type 8.
- Other names
- CACNA1CCACH2CACN2CACNL1A1CCHL1A1Voltage-dependent L-type calcium channel subunit alpha-1C
02
Mechanism of action
Inhibition of calcium channel activity
03
Biological functions
Calcium ion transportRegulation of muscle contractionRegulation of secretionRegulation of neurotransmitter releaseMemory formationFear response modulationCell-to-cell communicationCardiac action potential regulation
04
Disease associations
Timothy SyndromeLong QT Syndrome type 8Short QT SyndromeCardiac arrhythmia
05
Safety considerations
Cardiac arrhythmiasPotential for developmental delays (in Timothy Syndrome)
06
Interacting drugs
Dihydropyridines
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