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Target intelligence / Profile preview
Calcium Channel Protein Alpha1C Subunit (CaV1.2)
- Target
- CaV1.2
- Molecular classification
- Ion channel, Voltage-gated calcium channel
01
Overview
The calcium channel protein alpha1C subunit, also known as CaV1.2, is the pore-forming alpha-1 subunit of the voltage-dependent L-type calcium channel. It mediates influx of Ca²⁺ ions into cells when activated by changes in membrane potential (depolarization), playing a key role in shaping action potentials in cardiac and smooth muscle cells. Mutations or dysregulation are associated with cardiac arrhythmias and psychiatric disorders.
- Other names
- CACNA1CVoltage-dependent L-type calcium channel subunit alpha-1CCav α₁_C_Cav α11.2
02
Mechanism of action
L-type calcium channel antagonist
03
Biological functions
Calcium ion influxExcitation-contraction couplingNeuronal signalingSynaptic plasticityGene expression regulationHormone secretion
04
Disease associations
Cardiac arrhythmiasBipolar disorderVascular dysfunction
05
Safety considerations
HypotensionBradycardia
06
Interacting drugs
Dihydropyridines
2 more in the full profile.
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