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Calcium Channel Protein L-type Subunit Alpha-1C (CaV1.2)
- Target
- CaV1.2
- Molecular classification
- Ion channel, Voltage-gated calcium channel, L-type calcium channel
01
Overview
The alpha-1C subunit (CaV1.2) is the pore-forming component of the voltage-gated L-type calcium channel. It mediates calcium ion influx into cells upon membrane depolarization, triggering various cellular processes like contraction, secretion, and gene expression. It is crucial for cardiac and smooth muscle function, as well as neuronal signaling. Mutations and dysregulation are implicated in several disorders, including Timothy syndrome, Brugada syndrome, cardiac arrhythmias, and psychiatric conditions.
- Other names
- alpha-1C subunitCACNA1CVoltage-dependent L-type calcium channel subunit alpha-1C
02
Mechanism of action
Block L-type calcium channels
03
Biological functions
Calcium influxExcitation-contraction couplingSecretionGene expression (excitation–transcription coupling)Synaptic plasticity
04
Disease associations
Timothy syndromeBrugada syndromeCardiac arrhythmiasBipolar disorderSchizophreniaCardiovascular disease
05
Safety considerations
Cardiac effects (arrhythmias)Hypotension (due to smooth muscle relaxation)
06
Interacting drugs
Dihydropyridines
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